By Zeev Estrov (auth.), Lalitha Nagarajan (eds.)
Acute myelogenous leukemia (AML), is the commonest type of leukemia in adults. AML is a dangerous type of malignancy, the analysis for which has no longer more desirable within the final 20 years. extra importantly, it's a malignancy that's visible in older adults, accordingly the variety of circumstances is probably going to upward push because the inhabitants a long time.
Over the earlier 15 years, genetic mechanisms underlying AML have began to spread. extra examine during this sector has helped establish key elements and features. hence, specified treatment of AML is receiving a lot cognizance. it's the wish of researchers that as with continual myelogenous leukemia (CML), and the drug, Gleevec, a distinctive treatment for AML may be discovered.
"The potent remedy of acute myelogenous leukemia is still a good problem. this article reports our realizing of the molecular and biologic foundation of the ailment. top investigators handle advances in prognostication and healing recommendations that experience major promise."
Steven T. Rosen, M.D.
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Extra info for Acute Myelogenous Leukemia: Genetics, Biology and Therapy
Intermediate prognostic markers involve detection of a normal karyotype or presence of +6, +8, ÀY or 12p abnormalities.
Vorinostat (suberoylanilide hydroxamic acid, SAHA) is a hydroxamic acid that is highly potent in vitro. In a recent phase I trial of oral vorinostat for hematologic malignancies  several responses were observed in AML (9 of 31 patients, 29%), including 1 CR (duration, >6 months), 2 CRs without platelet recovery (duration, 4–6 weeks), 1 PR, and 5 complete marrow responses (blasts less than 5%). Depsipeptide is a cyclic tetrapeptide that is also a potent HDAC inhibitor in vitro . It has significant clinical activity in cutaneous T-cell lymphoma .
Expression of DNA methyl-transferase (DMT) and the cell cycle in human breast cancer cells. Oncogene. 1999;18(52):7453–7461. 121. Odenike OM, Alkan S, Sher D, et al. The histone deacetylase inhibitor depsipeptide has differential activity in specific cytogenetic subsets of acute myeloid leukemia (AML). Blood. 2004;104(11):(abstr 264). 122. Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999;99(3): 247–257.
Acute Myelogenous Leukemia: Genetics, Biology and Therapy by Zeev Estrov (auth.), Lalitha Nagarajan (eds.)